Left Atrial Myxoma With Atypical Echocardiographic Features

Accurate diagnoses of cardiac masses constitute a challenge to the cardiologist. Echocardiography plays an essential role, but differentiating between benign and malignant masses that may mimic the features of each other may not be easy by echocardiography. Myxomas are primary benign tumors of the heart with typical echocardiographic features that are generally found in certain locations in the heart. Nonetheless, they are occasionally found in atypical locations in the heart chambers and echocardiographic features mimicking malignant tumors. Myxomas may present with obstructive, embolic, and constitutional symptoms, or they might be found incidentally based on the tumor size and location. Herein, we describe a 78-year-old man with a cardiac mass with echocardiographic features inconsistent with a benign tumor, although further evaluation confirmed it as a myxoma. Benign or malignant cardiac masses could mimic the typical imaging features of each other, and the diagnosis should be based on pathologic findings. (Iranian Heart Journal 2022; 23(1): 233-236)