The Methionine Synthase Reductase (MTRR) A66G and Methionine Synthase (MTR) A2756G Polymorphisms Might be a Risk Factor for Colorectal Cancer in People Living near the Southern Coast of the Caspian Sea

A case-control study was designed to investigate the association between the risk of colorectal cancer and genetic variation in four single-nucleotide polymorphism (SNPs) within genes involved in folate metabolism: C677T and A1298C of methylenetetrahydrofolate reductase (MTHFR), A66G of methionine synthase reductase (MTRR), and A2756G of methionine synthase (MTR). Genomic DNA was extracted from peripheral blood of 80 patients with newly diagnosed colorectal cancer and 100 non-cancer controls. The statistical analysis was done by logistic regression. The results showed that the MTR and MTRR SNPs were significantly associated with an increased risk of colorectal cancer (p<0.01). Moreover, no significant association was found between MTHFR C677T and MTHFR A1298C polymorphisms and the risk of colorectal cancer. These findings suggest that the MTRR A66G and MTR A2756G polymorphisms might be some genetic risks factor for colorectal cancer in the studied population.