Hyperpyrexia After Rectal Misoprostol Administration-A Rare Side Effect of Misoprostol: Case Report

Misoprostol is a safe drug that is one of the prostaglandins analogs. It has uterotonic solid potential and is good for postpartum hemorrhage (PPH). Misoprostol has some side effects; hyperpyrexia is a rare side effect after misoprostol administration.

A 21-year-woman, Gravid 1 Parity 1, 18 hours after cesarean section, suffered from uterus atony and vaginal bleeding that rectal misoprostol was administered. Her PPH was managed with misoprostol and other uterotonics. She developedafever, and because of the Coronavirus disease (covid-19) pandemic, we suspected it and assayed it, but it was negative.

In this rare case, hyperpyrexia occurred after rectal misoprostol administration because of dose and prostaglandin effect on the hypothalamus. In this critical situation that covid-19 is pandemic, we suggest to specialists that keep in mind fever and hyperpyrexia may occur consequently the misoprostol administration.