Acute Response of Oxidative Stress and Muscle Damage Biomarkers to a Single Bout of Combined Training (Resistance-Aerobic) With Different Intensities Following Q10 Supplementation

Nutritional supplements and controlling the intensity of exercise are crucial to increasing muscle mass. However, the effect of these manipulations on the health of athletes may not be apparent. Thus, this study aimed to compare the effect of combined training (resistance-aerobic) with different intensities together with short-term supplementation of coenzyme Q10 on oxidative stress and muscle damage biomarkers.

45 male bodybuilders were divided into 3 groups, including: low, moderate, and high intensity combined training (n = 15). Research stages included initial blood sampling, 14 days of Q10 supplementation (400 mg/day), second blood sampling, a single bout of combined physical activity, and final blood sampling. In each group, first resistance training with different intensities of 55%, 70%, and 85% 1-RM was performed, and then aerobic training to consume 300 kcal at speeds of 8, 9.6, and 11.2 km / h was performed.

Q10 supplementation had no significant effect on baseline ​​levels of MDA, SOD, LDH, and CK (p≥0.05), but after performing low, moderate, and high intensity combined activities, a significant increase in the levels of MDA, SOD, LDH, and CK was found (p≤0.05).

Oxidative stress and muscle damage biomarkers increased in response to training intensity, but this increase was not significant in different intensities at fixed times. The individuals’ performance may have influenced the results of the present study. Given the lower aerobic capacity in male bodybuilders, the primary factor in increasing exercise pressure is exercise volume. Supplementation is also likely to be effective over long periods.