Changes in the Conventional Echocardiographic Findings due to Lipids Profile Variation in Children with Diabetes Mellitus Type I

Diabetes mellitus type I (DMT1) is a highlighted endocrine and digestive issue that involves the heart organs; with more effect when lipids profiles are considered. The study aimed to assess the variations in echocardiographic findings due to the changes in lipids profiles among children with DMT1.
This case-control study was performed on 96 DMT1 and 96 healthy children. The DMT1 was confirmed by clinical manifestations and laboratory measures. Both groups underwent conventional echocardiography and HbA1c; diabetic duration and lipids profiles were measured for the children with diabetes. Data was analyzed via SPSS 18.0 and P < 0.05 was considered as the significance level.
It was found that the left MPI was higher in patients (p=0.001) than in healthy controls. Patients with poor control had higher levels of LVMI and left deceleration time (p<0.05) compared to optimal controls. Patients with abnormal CHO had higher ejection fraction, fraction of shortening, Left E/A, LAd/Aod, LAs/Aos, left ejection time and PWD while right deceleration time, Aortic diameter in diastole, aortic diameter in systole, left MPI and left deceleration time had lower levels.  LDL changes affected aorta diameter in diastole, right deceleration time, aorta diameter in systole, left MPI and left deceleration time, fractional shortening, Left E/A, LAd / Aod, LAs/Aos, aortic ejection time and PWD. Patients with an abnormal HDL, had higher left MPI and lower left ejection time.
It was concluded that more conventional echocardiography involvement is observed in DMT1 children who have abnormal lipids profiles as well as abnormal HbA1c and longer diabetes durations.