The effect of Cinnamaldehyde on changes in the expression of C-jun, C-fos, P53 genes in cancer cells of wistar rat’s gastric tissue by dimethylhydrazine

Genes play a very important role in the development of the cancer. The aim of this study was to evaluate three very important genes (C-fos, C-jun and P53) in wistar mice stomach tissue cancer cells designed by dimethyl hydrazine.

In this study, forty male Wistar mice, 57 weeks old, were evaluated and divided into four groups of Ten. The control group, the second group received Cinnamaldehyde-free carcinogens, the third group was healthy with the Cinnamaldehyde, and the fourth group received carcinogens with the Cinnamaldehyde at the same time.Then, the gastric tissue of mice was isolated and evaluated for the expression of C-fos, C-Jun and P53 genes. The data was analyzed with One -way Anova using SPSS.

Statistical analysis of the results showed that the expression of C-fos, C-Jun and P53 genes in the carcinogen receptor with the Cinnamaldehyde was increased compared to the control group. This increase was statistically significant for two genes C-fos (P = 0.0146) and P53 (P = 0.0212) and for C-Jun gene (P = 0.01604) this increase was not significant.

The results of this study showed that Cinnamaldehyde can alter the expression of important genes C-fos, C-Jun and P53 that are effective in causing gastric cancer.