Prognostic Differences of Tumor Localization in Gastric Cancer Patients Undergoing Curative Resection

To investigate whether there is a relationship between tumour location and prognostic factors in gastric cancer.

Total 293 patients who underwent curative surgical resection for gastric cancer were retrospective analysed. Siewert Type II and III tumours were defined as PGC. More distally located tumours were defined as DGC. Siewert Type I tumours were excluded.

Of the 293 patients, 78 were diagnosed with PGC and 215 had DGC. There was a significant relationship between preoperative/postoperative chemotherapy administration, gastrectomy type, presence of lymphatic metastasis, TNM stage and tumour localization (p < 0.05). There was no significant difference between PGC and DGC in terms of length of hospital stay (p = 0.137). Five-year survival rates for PGC and DGC were 48.4% and 45.8%, respectively (p = 0.863). pT stage, preoperative and postoperative chemotherapy were determined as independent risk factors (p < 0.05). The location of the tumour and the type of surgical resection did not affect the prognosis (p > 0.05).

Tumour localization is not a prognostic factor in gastric cancer. When safe surgical margins were provided in DGC, total gastrectomy for DGC did not affect survival.