Effect of Sofosbuvir on Length of Hospital Stay in Moder-ate COVID-19 Cases; a Randomized Controlled Trial
Efforts to control the COVID-19 pandemic are still on. This study aimed to evaluate the effect ofsofosbuvir on length of hospital stay and complications in COVID-19 cases with moderate severity.
This randomized clinical trial was done on moderate COVID-19 cases, who were admitted to Shohadaye TajrishHospital, Tehran, Iran, from 4/2021 to 9/2021. Eligible patients were randomly allocated into two groups ofintervention (sofosbuvir) and control, and their outcomes were compared regarding the length of hospital stayand complications.
100 COVID-19 cases were randomly divided into two groups of 50 patients, asthe intervention and control groups. The mean age of patients was 50.56 ± 12.23 and 57.1±14.1 years in theintervention and control groups, respectively (p = 0.02). The two groups were similar regarding distribution ofgender (p = 0.15), underlying diseases (p = 0.08), the severity of COVID-19 (p = 0.80) at the time of admission,signs and symptoms (p > 0.05), and essential laboratory profile (p > 0.05). The length of hospital stay in thecontrol and intervention groups was 7.7 ± 4.09 days and 4.7±1.6 days, respectively (p = 0.02). None of our patientsneeded ICU or mechanical ventilation.
Sofosbuvir may decrease the length of hospital stay ofCOVID-19 cases with moderate severity, without a significant effect on the rate of intensive care unit (ICU) needand mortality.
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