The effect of high, low and moderate intensity circuit resistance training on the levels of hepatocyte-derived fibrinogen-related protein 1 (HFREP1) and lipid profile in obese postmenopausal women

Different hepatokines including the hepatocyte-derived fibrinogen-related protein 1 (HFREP1) are secreted by liver tissue, which can affect the lipid metabolism. The aim of present study was to investigate the effect of 12 weeks circuit resistance training with different intensity on the levels of HFREP1 and lipid profile in obese postmenopausal women.

Subjects of the study consisted of 44 postmenopausal women with average age of 56.07 ± 3.18 years old, dividing into the circuit resistance training with low (L-RT), moderate (M-RT), high (H-RT) intensity and the control groups (11 subjects in each group). Training program was conducted for 12 weeks and three session per week. Blood samples collected in pre and post-test stages and the levels of HFREP1 were measured by ELISA method and finally data was analyzed by Graphpad Prism software.

Analysis of HFREP1 data indicated that there were significant differences between different groups (P < 0.001). The results of Bonferroni post hoc-test showed that there was no significant difference between the control and L-RT groups (P > 0.05). However, HFREP1 in M-RT and H-RT groups significantly decreased compared to control group (P < 0.001). In addition, HFREP1 decrease in M-RT and H-RT groups was significant compared to L-RT group (P > 0.05). Lipid profile also improved in all trained groups, which further improvement observed in the H-RT group.

It seems that, higher intensity circuit resistance training is associated with further decrease in the levels of HFREP1, and improving the lipid profile can be attributed partly to downregulation of HFREP-1 levels.