A Studying the myoglobin changes and its effect on sepsis severity and outcome

Sepsis refers to a set of systemic inflammatory responses to infection that cause harmful effects on the human body. Myoglobin can be used as a beneficial marker in determining the status of patients with sepsis. This study aims to investigate the changes in myoglobin and its effect on the severity and outcome of sepsis in the hospital.

In this study, patients were divided into three groups: sepsis, severe sepsis, and septic shock. Data about their age, gender, myoglobin level in 4 different times (entrance time, 6, 12 and 24 hours later) and sofa index was obtained and compared. Blood culture was taken for all patients and results were evaluated for gram-positive or gram-negative.

The patients of the three groups were not significantly different in terms of age (P=0.59) and heart rate (P=0.18). While in terms of myoglobin, there was a significant difference in every 4 times (P=0.00), hospital days (P=0.01), fever (P=0.00), and SOFA (P=0.00) so that with increasing sepsis severity, this Variables rate increased. There is no significant difference in the gender distribution ratio between groups (P>0.05). The highest rate of involvement in each group of patients is related to the respiratory tract. The outcome of patients (survival/death) in different groups is significantly different (P=0.00). A higher percentage of the cultures was gram-negative and the frequency of cultures was not significantly different between different groups. (P-value=0.86).

The level of myoglobin measured in patients had an increasing trend. Elevated myoglobin levels were also significantly associated with sepsis and mortality.