The role of Demineralized Bone Matrix (DBM) in bone defect healing in animal and human models

usually Bone defect occurs because of cysts, tumors, osteotomies, etc... During the past 50 years, various materials have been used as bone substitutes and bone graft. There is no ideal bone substitute or bone graft for use in all conditions. Bone grafting include: autograft, allograft, xenograft , and santetic material. Synthetic DBM is commonly used as an allograft, characterized by osteoinduction and osteoconduction but without osteogenicity due to processing.DBM is achieved when the minerals of bone be removed by using acid ( usually HCL or nitric acid ) Using DBM is affordable and available in abundance. There are numerous DBM formulations based on their manufacturing techniques. They are used as frozen powders, granules, gels, cements or tapes. DBM is used for bone defects healing because of cysts, tumors, etc… and especially in long bones defects. In most studies, the use of DBM in bone defect repair has been effective and useful.