The Relationship between Bone Mineral Density and Serum Vitamin D Levels in Cystic Fibrosis Children

Cystic fibrosis is a multisystemic disorder. It is the most common autosomal recessive disorder in whites that causes complications such as changes in bone density. Therefore, evaluating bone densitometry and serum levels of vitamin D in children with cystic fibrosis is the aim of our study.
This study was performed on 54 children with cystic fibrosis. After recording demographic information, bone densitometry and serum levels of vitamin D were recorded. Chi-square and Pearson correlation tests were used to compare data.
Based on our study 53.7% of patients with CF had vitamin D less than 20 nmol / l. It was also found that based on lumbar BMD, 20.3% had a BMD less than 2.5 - Based on femoral BMD, 18.5% had a BMD less than -2.5. And our results demonstrated that there is no relation between BMD with vitamin D, calcium and phosphorus but it is significantly correlated with age, height, weight, and BMI.
Decreased BMD is high in patients with CF; on the other hand there is a deficiency of vitamin D in more than 50% of these patients to whom vitamin D supplements should be prescribed along with the standard treatments. Further studies are also required to investigate the effect of other factors on BMD.