Underestimated Aspects in Male Infertility: Epigenetics is A New Approach in Men with Obesity or Diabetes: A Review

Infertility is a complex multifactorial problem that affects about 7% of men and 15% of couples worldwide. Many molecularmechanisms involved in male infertility. Destructive effects of infertility on the next generations are not wellunderstood. Approximately 60-75% of male infertility cases have idiopathic causes, and there is a need for additionalinvestigations other than routine examinations. Molecular factors that surround DNA, which are mitotically stable andindependently regulate genome activity of DNA sequences, are known as epigenetics. The known epigenetic mechanismsare DNA methylation, histone modifications and non-coding RNAs. Prevalence of metabolic diseases has beenincreased dramatically because of changes in lifestyle and the current levels of inactivity. Metabolic disorders, suchas obesity and diabetes, are prevalent reasons for male infertility; despite the association between metabolic diseasesand male infertility, few studies have been conducted on the effects of epigenetic alterations associated with thesediseases and sperm abnormalities. Diabetes can affect the reproductive system and testicular function at multiple levels;however, there are very few molecular and epigenetic studies related to sperm from males with diabetes. On theother hand, obesity has similar conditions, while male obesity is linked to notable alterations in the sperm moleculararchitecture affecting both function and embryo quality. Therefore, in this review article, we presented new and developedtechnologies to study different patterns of epigenetic changes, and explained the exact mechanisms of epigeneticchanges linked to metabolic diseases and their relationship with male infertility.