Association study between schizophrenia and the DISC1 gene polymorphism

The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large Scottish family.

Our samples included 200 unrelated patients diagnosed with Schizophrenia on the basis of DSM-IV criteria and 200 normal controls, which were gathered from Iran. The allele and genotype frequencies of the polymorphism were determined using Polymerase Chain Reaction-Restricted Fragment Length Polymorphism (PCR-RFLP) and the data were analyzed by Logistic Regression test.

In this study we genotyped the rs821616 polymorphism (Serin704Cystein) located within exon 11 of the DISC1 gene. The samples were matched on the basis of sex and ethnicity. We used the case control study to determine the possible association between the ser704cys (rs821616) polymorphism and Schizophrenia. Analysis of data in the samples, revealed no association between the rs821616 polymorphism and Schizophrenia (OR= 0.697, 95% CI= 0.47-1.033, P=0.072).

In this study we did not find any association between the rs821616 SNPand schizophrenia.