The Effects of Sodium Nitrite on Embryonic Parmeters (Head Length, Head Width, Body Length, Body Weight) in Rats

  Nitrite is widely used in food, pharmaceutical and chemical industries. In this study, the effects of sodium nitrite poisoning on embryonic parameters (Head length, head width, body length, body weight) in male and female rats were investigated. 

In this experimental study, 30 adult Wistar rats were randomly divided into two groups of 15, including sham group and experimental group receiving sodium nitrite (175 mg / kg / day) in drinking water for 4 weeks. Forty-eight female rats were randomly divided into three groups of 16 including the sham group, the experimental female group receiving sodium nitrite (175 mg / kg / day) in drinking water for 2 weeks, and the experimental female group receiving 2 sodium nitrite (175 mg / kg / day). ) Were divided in drinking water for 4 weeks. After mating, pregnant rats were treated with sodium nitrite according to the previous dose. Newborns were removed and tested for microscopic abnormalities. Body weight, head length, head width and body length were measured and statistically analyzed.

The mean head length in the treated female groups (two weeks) - sham male and female - treated male showed a significant increase compared to the sham female and sham male groups. The mean head width in the treated female (two weeks) - sham male group and treated female (two weeks) - treated male group compared to the sham female group - male sham showed a significant increase. Mean body weight in drug group (two weeks) - sham male and drug female (two weeks) - drug male compared to sham  female group - sham male showed a significant increase. The mean body length in the female (2 weeks) and male-drug-drug (female) (2 weeks) and sham male groups showed a significant increase compared to the female sham -male sham groups (P <0.05)

It seems that administration of sodium nitrite disrupts the embryonic parameters (head length, head width, body length, body weight) of neonatal rats.