Effect of 6 weeks Pilates training along with dill supplementation on serum concentrations of nesfatin 1, lipocalin 2, and insulin resistance in females with overweight and obesity: A randomized controlled trial

This study aimed to investigate the effect of 6 weeks’ pilates training along with dill supplementation on serum concentrations of  esfatin?1, lipocaline?2, and insulin resistance in females with overweight and obesity.

In this randomized controlled trial study, 45 overweight and obese females are randomly assigned to four groups: Pilates training + dill group (PDG) (n = 12), pilates training + placebo group (PPG) (n = 11), dill supplementation group (DG) (n = 11), and placebo group (PG) (n = 11). Participants of PDG and PPG performed pilates training for 6 weeks (60 min, 3 sessions per week). PDG and DGreceived dill tablet (three times a day, 6 weeks). Anthropometric  easurements, glycemic markers, and blood samples were assessed before (pretest) and after (posttest) 6 weeks of intervention.

Results showed a significant increase in serum concentrations of  esfatin?1 in PDG compared to pretest (P = 0.001). Differences in the  erum concentrations of nesfatin?1 in PDG were greater than PPG, DG,  and PG (P = 0.01). Furthermore, results found in significant reduction in serum concentrations of lipocalin?2, body mass index (BMI), and waist?hip ratio (WHR) in PDG, PPG, and DG as compared to pretest (P > 0.05). Fasting glucose plasma (FGP) was significantly decreased in all three intervention groups PDG (P < 0.001), PPG (P < 0.001), and DG (P < 0.001) as compared to pretest. Differences in FGP were significantly higher in PDG than PPG, DG, and PG (P = 0.001). A significant reduction was found for insulin only in PDG after 6 weeks of intervention as  ompared to pretest (P = 0.03). Insulin resistance significantly decreased in PDG (P = 0.03) and PPG (P = 0.04) as compared to pretest. Body fat percent (BFP) was significantly decreased in PDG (P = 0.003), PPG (P = 0.006), and DG (P = 0.01). However, there were no significant inter?group differences in insulin resistance, insulin, serum concentrations of lipocalin?2, BMI, BFP, and WHR after 6 weeks of Pilates training along with dill supplementation (P > 0.05).

We concluded that 6 weeks of Pilates training along with dill may be beneficial for improvements in serum concentrations of nesfatin?1 and FGP.