Defining of Mechanical Properties of Ago-1522 Living Cell Using Atomic Force Microscope

In general, every normal cell of the human body, which consists of different parts such as the nucleus, cell membrane and protein nanofibers, has a certain mechanical hardness and strength. Any noticeable change in this strength indicates a disease. One way to diagnose various diseases such as cancer in normal cells of the human body is to measure the amount of changes that have occurred in their mechanical properties. In the present paper, mechanical properties including modulus of elasticity and adhesion force of Ago-1522 cell, which is considered as a natural skin cell, using JPK atomic force microscope (made in Germany), Nano Wizard 3 in both extension and retraction modes, and obtained at a temperature of 37 degrees Celsius. Based on the results, the average elastic modulus for the cell in the extension mode (as the valid mode in the reports) is equal to 574.4 Pa. The adhesion force is equivalent to N in retraction mode. Based on images taken from the surface of the cell with an atomic force microscope, its maximum height is 0.4 micrometers.