Epidemiological study of sleep disorders and clinical symptoms in patients with celiac disease in Khorasan Razavi province

The present study was conducted with the aim of investigating the epidemiology of sleep disorders and clinical symptoms in patients with celiac disease in Razavi Khorasan province. This descriptive research is causal-comparative.

In this study, 260 patients with celiac disease were selected according to Morgan's table among those who referred to Imam Reza Hospital in Mashhad, who were diagnosed by a gastroenterologist and underwent intestinal biopsy. 260 healthy people were selected by available sampling method and in one step they were asked the Epworth Sleepiness Status (ESS), Insomnia Severity Index (ISI), Restless Leg Syndrome (RLS) and Obstructive Sleep Apnea (OSA) questionnaires. Berlin), Sleep Quality Index (PSQI) and Depression, Anxiety and Stress Questionnaire (DASS). Analysis of variance was used by spss22 software to analyze the data.

There is a significant difference between celiac disease patients and healthy people in sleepiness, insomnia severity, restless leg syndrome, obstructive sleep apnea and clinical symptoms (p<0.001). The effect size index showed that 12% of sleep disorders and clinical symptoms are related to the effect of celiac disease, and the group of patients with celiac disease has a higher average Ttg1 status than Ttg2.

Sleep problems cause a series of inflammatory factors in the body, and according to this research, it can be concluded that gluten-free diet has an effect on controlling these factors and thus reducing sleep disorders in celiac patients.