Calculating the Young's modulus of head and neck cancer cells during the nanomanipulation process using atomic force microscope

Head and neck cancer is a disease that often affects the mouth, throat and nose. This type of cancer causes damage to other cells and complications such as hearing and taste damage through treatment methods such as surgery and chemotherapy. Studies have been done on the use of nanoparticles as drug carriers, understanding the structure of cancer cells and investigating their mechanical properties. In this study, in order to improve the treatment and early diagnosis of this type of cancer, the Young's modulus of head and neck cancer cells was estimated using the nanomanipulation process. The topographic images and experimental graphs used were extracted by exploring the head and neck cancer cells under AFM. The main innovation of this research has been in the use of JKR, MD and Tatara contact models. The main aim of the research is to draw indentation depth graphs according to applied force to estimate Young's modulus of Head and Neck tissue. By comparing the theoretical and experimental results of the 12 KPa Young modulus with the JKR model and the value of 11 KPa with the Tatara contact model, the values of the Young modulus of the head and neck cancer cell are estimated.