Dynamic Population of Gut Microbiota as an Indicator of Inflammatory Bowel Disease

Inflammatory bowel disease is a group of conditions of the intestine. The gut microbiota is an important factor in the pathogenesis of IBD. Due to a link between the gut microbiota and IBD, studying microbiota changes using an accurate, sensitive and rapid method for rapid detection of the disease seems necessary. This study aimed to compare the composition of gut microbiota in three groups of people, including IBD patients, CIBD, and healthy groups.

For this study, 45 stool samples (15 from each group) were collected. Using real-time PCR, the abundance of 11 bacterial 16S rRNA gene sequences was examined.

In the IBD group, the number of three bacterial phyla, including Firmicutes, Actinobacteria, and Bacteroidetes, decreased, while the population of γ-Proteobacteria increased significantly. In the CIBD group, the number of Actinobacteria enhanced, but that of Bacteroidetes and Firmicutes decreased.

Finding of this study indicate that decrease of Firmicutes and increase of γ-Proteobacteria could be used as an indicator of IBD instead of employing invasive and costly detection methods such as colonoscopy and other tests.