The Effect of High- and Low-Intensity Interval Training on Myostatin Gene Expression Levels in Muscles Fibers of Rats with Myocardial Infarction
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction
Myocardial infarction (MI) is an essential coronary artery disease, which affects mitochondrial function and causes muscle atrophy due to vessel blockage and disruption in blood transfusion and oxygen transfer. Interval exercises reduce muscle atrophy, but the appropriate exercise intensity is still unknown. This study aimed to evaluate the effect of interval training with two for six weeks on Myostatin gene expression levels in slow (ST) and fast (FT) twitch muscles in rats with MI. Method
Eighteen ten-week male Wistar rats with MI were randomly assigned into high- (HIIT) (90-85% VO2max) and low-intensity interval training (LIIT) (50-60% VO2max) with a control group (CG, without training). Myostatin gene expression of FT and ST was investigated as a stimulant of muscle atrophy. The training protocol was 30-minute intermittent jogging sessions on a treadmill. Each interval included 4 min of running (85-90% VO2max for HIIT and 55-60% for LIIT) and 2-minute active recovery (50-60% for HIIT and 45-50% for LIIT) three days a week for six weeks. Results
LIIT significantly decreased myostatin expression in both ST and FT while HIIT only decreased myostatin expression in ST compared to CG (P = 0.002, P = 0.016, and P=0.011, respectively). HIIT induced myostatin expression reduction was higher in FT compared to CG (P = 0.078). There was a significant difference in myostatin expression between CG (8.87) and the two training groups (HIIT [0.949] and LIIT [3.11]) in ST (P≤0.05), and between CG and LIITs and HIIT (1.22) and LIIT (0/975) in FT (P<0.05). Conclusion
Six weeks of HIIT and LIIT reduced myostatin gene expression and decreased ST and FT atrophy in rats with MI.Keywords:
Language:
English
Published:
Journal of Nutrition, Fasting and Health, Volume:10 Issue: 4, Autumn 2022
Pages:
295 to 299
magiran.com/p2519017
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!