Optimal Laser Control for Cancer Thermal Therapy

Today, various treatments such as surgery, chemotherapy, radiotherapy and hyperthermia are used to treat cancer. The best treatment for cancer treatment is to predict and accurately control the distribution of temperature in the damaged tissue, which has been the subject of many studies in recent years. In most studies, it has been observed that, due to the increased temperature in cancer treatment, and especially in the hyperthermia, the healthy tissue adjacent to the damaged tissue also disappears and results in bad consequences. In this paper, the optimal laser control for cancer therapy has been done. To this end, according to the non-Fourier behavior of temperature transitions in laser treatments, the time-dependent transient temperature distribution in one-dimensional mode, along with the heat of metabolism and perfusion of blood, using the Pence heat transfer equation, is analyzed. In order to minimize the damage to the healthy tissues adjacent to the damaged tissue, the objective function includes the difference between the calculated thermal damage with the desired thermal damage is defined. Therefore, the thermal flux value is optimized as an optimal control problem and the lowest and most useful value is obtained. Finally, the results of the numerical solution of this problem are extracted and shown for triangular thermal flux and square heat pulses.