Phlebosclerosis is defined as the fibrous degeneration of the venous wall, though in history, it has been defined from endophlebitis to hyalinzation of the intima of the venous wall, the actual pathology is obscure. We present a case series of three different cases from three different decades of life, 5th, 6th, 7th  respectively with varied co-morbities, in which we encountered phlebosclerosis , while harvesting GSV for CABG.: To author’s knowledge, this is the first ever indigenous study on phlebosclerosis of GSV, the study would give a excerpt into the continuum on the natural history of the disease. The literature is reviewed and the case is presented.