Aptamer, applications and its design in silico method

Aptamers are single-stranded sequences of RNA, DNA, or highly specific proteins that tend to bind to a wide range of target molecules. Aptamers are widely used in various fields, especially medicine and diagnostics, and are similar in their application to antibodies. There are many benefits to using aptamer instead of antibodies, such as low cost, longer life, increased tissue permeability, and more. There are several methods for producing aptamer that in silico methods can shorten and simplify the steps of aptamer production. With aptamer modeling, a set of in silico methods such as modeling, docking, and molecular dynamics can be used to screen for the best aptamer sequence. In this article, a review of the types of aptamers, their structure and design methods in silico is briefly stated.