Mechanical Specifications of the Skin Normal and Cancerous Cells Using Atomic Force Microscope

Deformation of cells and changing in mechanical specifications is one of the most important of cancer as serious illness. In fact, variation of mechanical properties of the cells is one of the important effects of the cancer. Here, the mechanical specifications of normal and cancerous skin cells have been studied. HU02, A-375 and A-431 as the normal and cancerous skin cells respectively have been investigated. The mechanical specifications including elasticity modulus and adhesion have been obtained using nanoindentation using JPK Instruments-Nano Wizard 3 atomic force microscope (AFM). The JPK SPM Data Processing software (v.5.0.96) was used to obtain the mechanical specifications. The results show that cancer can decrease the elasticity modulus of the cells to half in skin and increases the adhesion up to 38 times rather than normal cells. The cancerous cells are more adhesive than normal cells. The height of the cancerous cell is greater than normal cell.