Investigation of electron beam irradiation effect on spikes of SARS-COV2, MERS-COV, UK variant, SARS-COV by Geant4-DNA toolkit

Viruses pass cell walls and enter cells using their spikes, So one of the efficient ways to stop viral infections is to disturb their spikes functionality. In this research, the process of energy absorption and transfer by SARS-COV2, MERS-COV, UK-COV, and SARS-COV spikes was studied. In this research sample viruses exposed to radioactive radiations and results were compared by Geant4-DNA and analyzed. A strategy to reduce the virus life cycle is energy absorption. In this research, the response to viruses spikes to radiation was simulated. Samples were exposed to 10 eV–2 keV electron beams. The level of Energy absorption and its relation to the number of infected patients was studied. It was concluded there is an inverse relationship between absorbed energy level and patient death.