Determinant Factors Impact of E-Health Literacy on the Quality of Life of Students During the Covid-19

University students’ quality of life (QoL) impacts on their quality of learning, academic achievement and knowledge. An increased risk of deterioration in QoL was happened during the COVID-19 pandemic for university students. The focus of this study is on the impact of university students’ electronic health literacy on their QoL and its determinants during the Covid-19 pandemic. This cross- sectional study was conducted by two valid and reliable questionnaires on 260 health students at Semnan University of Medical Sciences in Iran in 2021. E-Health Literacy Scale and World Health Organization QoL questionnaire were used. The link of the online questionnaire was sent to the students. A reminder message was sent to the users, if the online questionnaire was not completed and answered within a specified time. Multiple logistic model regression analysis was used.  About 84.2% of students had sufficient e-Health literacy and 76.4% had a good QoL. The students’ e-Health literacy had a significant relationship with English language skills (P = 0.30, OR = 1.929), Internet skills (P = 0.008, OR = 1.740), start searching for health information on the Internet (P <0.001, OR = 4.840) and information search method in Internet (P = 0.007, OR = 1.650). There was a significant relationship between students' e-Health literacy and their QoL (P <0.001, OR = 3.466). Present study shows indicators that encourage university students to involve in electronic health tools and to improve their QoL during the COVID-19 pandemic. These indicators are worth and should be considered when developing medical education, self-management programs and formulating interventions.