Preparation of cyclodextrin functionalized graphene nanosheets and its application in electrochemical determination of imipramine

In the present study, a glassy carbon electrode (GCE) modified with cyclodextrin graphene organic-inorganic hybrid nanosheets (CD-GNs) was prepared and applied for the sensitive electrochemical determination of imipramine (IMP). The surface morphology of the proposed electrode was characterized by scanning electron microscopy. Electrochemical results clearly demonstrated that CD-GNs organic-inorganic hybrid nanosheets could exhibit very high supramolecular recognition and enrichment capability. The effect of experimental conditions such as pH and scan rate were also investigated. Using differential pulse voltammetry (DPV), the modified electrode was applied for the sensitive determination of IMP in the range of 0.24-25 µM at pH 7.0. The limit of detection (S/N=3) was 47 nM. The RSD was obtained 1.75% which demonstrated the good repeatability of the fabricated electrode for IMP determination. Cyclic voltammetry (CV) was also used to attain information about the oxidation mechanism and calculating kinetic parameters. The proposed nanocomposite electrode exhibits good applicability for monitoring IMP in pharmaceutical formulations.