Unilateral acute central serous chorioretinopathy with inactivated coronavirus disease 2019 vaccination: A case report and review of literature

To report unilateral acute‑onset central serous chorioretinopathy (CSC) following vaccination with inactivated coronavirus disease 2019 (COVID-19) vaccine in a healthy patient.

Case report and review of literature.

A 39‑year‑old male was referred with sudden‑onset, painless, unilateral blurred vision in the right eye. His first dose of the Sinopharm vaccine was injected 2 days before. A complete ocular examination revealed central subretinal fluid (SRF) accumulation in favor of CSC in the right eye. Systemic workup disclosed no previous COVID‑19 infection or any systemic involvement. After 3 weeks, SRF decreased remarkably without treatment.

It is proposed that CSC development can be an ocular adverse effect of COVID‑19 vaccination, although it is infrequent. Ophthalmologists should be aware of the possible association between COVID‑19 vaccination and ocular adverse effects, but vaccination is the best effectual measure against COVID‑19.