Investigation of Parameters Affecting the Geometry of Red Blood Cell Using Low-Dimension Model in Dissipative Particle Dynamics

Approximately one half of the blood flow is made up of the Red Blood Cells (RBCs). Moreover, the geometry of the RBCs relative to the vessel diameter greatly effect on the physics and dynamics of the blood flow. It means the quantitative understanding through the vessels is important in multifarious pathologies. To simulate RBCs, one of the modelling concerns is related to the details required for the sufficient accuracy and another is about the cost of computational methods. The mesoscopic models of RBCs combined both parameters accuracy and optimality. Then to achieve some of these goals in this study a numerical model called Low-Dimensional (LD) model along with DPD method are used to simulate Red Blood Cells, RBCs, in blood flows. LD-DPD model is developed due to new formulation of single particle in DPD and is able to capture the essential mechanics properties of these suspensions economically because of the low number of particles. The advantage of LD model is the use of spherical particles compared to the standard DPD which assumes point particles. For instance, in this study, to simulate a RBC, only10 colloidal particles are required. Also it is proved in this work different parameters are effective to determine the RBC radius and using this method, it is easy to investigate them until to match this simulation with the real one.