In the present study, the response surface methodology is used to predict the bubble departure frequency of pure liquids using experimental data. Water, ethanol and methanol pure liquids were used as the testing fluid. The effects of vapor and liquid density difference, vapor and liquid viscosity, surface tension, thermal conductivity, heat flux on the vapor bubbles departure frequency on the heat transfer of boiling pool of pure liquids were investigated by response surface methodology. The results showed that the output of the Response surface methodology had a good overlap with the data of bubbles departure frequency of pure liquids. Also, the results for the bubble departure frequency show a good overlap between the models presented by the researchers and the experimental data and have good accuracy. In this research, a new model for the prediction of vapor bubble departure frequency, based on the Buckingham theory, in nucleate boiling is proposed, which predicts the experimental data with a satisfactory accuracy (9%).