Electropolymerized β-cyclodextrin as an Efficient Recognition Element Toward a Highly Sensitive Electrochemical Sensor for Sumatriptan

The present study aims to introduce a highly sensitive electrochemical sensor for quantification of trace amounts of Sumatriptan (SUM) in biological fluids. To immobilize a stable nano film of β-cyclodextrin (β-CD) on a glassy carbon electrode (GCE), electropolymerization of monomer was carried out within 0.1 M phosphate buffer with pH 6.0 utilizing cyclic voltammetry to yield polymerized β-CD (pβ-CD). The morphological characterization of pβ-CD/GCE was examined by Field emission scanning electron microscopy (FESEM). The electrochemical redox action of SUM on pβ-CD/GCE was scrutiny studied by cyclic voltammetry and chronocoulometry. The electrochemical parameters including the electron transfer coefficient (α), the standard heterogeneous rate constant (ks), the surface area of the electrode (A), the electron transfer number (n), and the surface coverage (Γ) were estimated to be 0.38, 1.23×10-3 cm s-1, 0.06 cm2, 1, 1.07×10-8 mol cm-2, respectively. At optimized criteria, a substantial enhancement was attained toward the electrooxidation of SUM on the developed electrode compared to the bare GCE, resulting in wide linear ranges of 0.0622.47µM and 2.4752.1µM with a low detection limit of 27 nM. The developed sensor was successfully employed for quantification of SUM in human blood serum and urine samples with good selectivity and acceptable recoveries, proving its utility for further applications as a sensitive and reliable sensor.