Supplemental Preparations in Taxane-Induced Neuropathy Management

Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting adverse effect of chemotherapy without anyspecific treatment. The aim of this paper is to evaluate the effects of natural products and supplements onTIPN. PubMed, Google Scholar and Web of Science databases were searched through August 2022 regardingTIPN and effects of natural products and supplement therapy. Data consists of preclinical studies, randomizedcontrolled trials and case reports. After screening of 230 papers, we found 13 relevant animal and human studiesregarding possible benefits of vitamin E, glutamine, omega-3, acetyl-L-carnitine and group of B vitamins onTIPN. Results demonstrated that vitamin E can be helpful on prevention and duration of TIPN. Glutamineand B vitamins showed hopeful results on reducing pain sensation. Omega-3 also shows promising resultson incidence of TIPN. However, acetyl-L-carnitine might develop and worsen neuropathy. Although somesupplements revealed promising effects on prevention and treatment of TIPN, researches are still limited andwe need further long-term large sample size trials to confirm clinical efficacy of these supplements.