In Vitro Evaluation of Manganese-Containing Glass-Ceramic in Quaternary SiO2-CaO-Na2O-P2O5 System

In this research, sol-gel experimental conditions are imposed to prepare a new Mn-containing SiO2-based bioactive glass. The current study primarily aims to investigate the impact of the presence of manganese ion on the glass structure, bioactivity, and cytotoxicity. The obtained glass-ceramics were characterized using a X-Ray Diffractometer (XRD). According to the observations, crystallization of silicorhenanite and calcite phases in the manganese-containing sample were inhibited before and after soaking in the simulated body fluid (SBF), respectively. In vivo bioactivity evaluation confirmed the bioactive nature of the obtained powders. Finally, the cellular test was carried out, the results of which demonstrated non-cytotoxicity of the samples towards human Bone Marrow Stromal Cells (hBMSCs) cells up to 7 days.