Synthesis and Characterization of Cisplatin Magnetic Nanocomposite

Nanotechnology is a branch of science that that has opened new research horizons, particularly in the field of ofmedicine and cancer treatment.In the present paper, magnetite nanoparticles (Fe3O4) were produced by the co-precipitating of two and three valent iron chloride salts in an alkaline medium. The surface of the nanoparticles was functionalized with (3-Aminopropyl)-trimethoxysilane(APTS), and finally the cisplatinanticancer drug was loaded onto the modified nanoparticles. Properties, structure and morphology of the nanoparticles obtained were evaluated and analyzed by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Vibrating Sample Magnetometer (VSM) for measuring magnetic properties. Results showed that cisplatinwas attached to the surface of the nanoparticles confirmed by FT-IR analysis. Magnetic properties using VSM results showed that the nanocomposite is the result of superparamagnetism. Findings showed that magnetic cisplatin magnetic nanocomposites are promising for targeted magnetic drug delivery and can be used as a targeted nanoparticle suitable for delivering anticancer drugs.