Response of Liver Tissue Oxidative Indices to Bisphenol-A intoxicated Rats to Eight Weeks of Aerobic Training with and without Zinc Supplementation (Zinc Nanoparticles and Nanoparticles)

The purpose of this study was to investigate the effect of moderate-intensity aerobic exercise with and without supplementation of nanoparticles and zinc oxide salts on hepatocyte oxidative markers in BPA-intoxicated rats.

60 male rats were divided into 12 groups: 1) Control; 2) BPA; 3) Exercise; 4) Exercise+BPA; 5) Nanoparticle supplementation (Nano); 6) Nanoparticle+BPA (Nano+BPA); 7) Zinc oxide salt (Zno); 8) Zinc oxide salt+BPA (Zno+BPA); 9) Exercise+Nano; 10) Exercise+Nano+BPA; 11) Exercise+Zno; and 12) Exercise+Zno+BPA. The exercise program was performed for eight weeks with 50-75% VO2max for 25 to 64 minutes. Nanoparticles supplemented give with 5 mg/kg 5 days a week for eight weeks.

The activity of the antioxidant enzymes GPX, SOD and Catalase increase significantly in the BPA group in addition to the increase in the exercise group, but TAC status decreased significantly in the exercise group alone (p = 0.001) and Zno and NanoZno groups significantly increased this index compared to the healthy control group (p = 0.001). Interestingly, in MDA and AOPP, the BPA groups showed a significant increase in these variables, supplementation caused a significant decrease in these variables, and the highest reduction was in BPA+Nano and BPA+Zno (p = 0.001).

BPA causes reactive changes in antioxidant capacity, it destroys total antioxidant capacity. However, oxidative index studies revealed that a combination of moderate-intensity exercise and zinc oxide supplements (especially supplementation alone) may alter the kinetics of BPA contamination by inhibiting the oxidative system and subsequently improving hepatocyte status.