Association of ABO ,Rh Blood Groups with the Susceptibility of Gestational Diabetes in the Yazd-Iran Population

Today, the association of blood groups as genetic traits has been confirmed in many diseases. However, its association with gestational diabetes mellitus (GDM) has not been investigated. Therefore, in this study, we investigated the relationship between blood groups and GDM.

In this analytical cross-sectional study, pregnant women referred to Baqaeipur Clinic and Yazd Diabetes Research Center in 2015-2018Based on the information related to the results of the one-hour OGTT test and the two-hour glucose levels recorded in the file were divided into two groups (GDM, non GDM). Then other information about the participants in the study, including demographic information, medical history, ABO and Rh blood groups, abortion, delivery, and number of pregnancies were extracted from the file and analyzed using SPSS version 23 software.

Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P< 0.001), weight (P< 0.001), number of pregnancies (P< 0.001), delivery (P< 0.001), previous diseases (P< 0.001), and Rh (P= 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed.

Finally, we concluded that the frequency of the B+ blood group is higher in the GDM group, however, there is no statistically significant relationship between ABO blood groups and GDM.