Application of Dental Pulp Stem Cells in Modern Dentistry: A Narrative Review

Dental pulp stem cells(DPSCs) are a class of stem cells which originate from dental pulp tissue and possess multiple stem cell characteristics including high clonogenicity, differentiation capacity and immunomodulatory effects.  DPSCs can be used in different stem cell-based therapy to treat a variety of diseases, such as autoimmune, orthopedic, and neurological diseases.Recent studies showed that DPSCs combined with biomaterials provides an effective approach to craniofacial bone regeneration and reconstruction of bone defects. Scaffolds improve cell attachment, proliferation, differentiation, and migration. In the present study we discuss different combination of biomaterials with DPSCs.