Eco-Friendly Synthesis of MgO/MgAl2O4 Core/Shell Nanostructures and their Antimicrobial Evaluation Against Pathogenic Microbial Strains

Nowadays antimicrobial resistance is one of the important concerns caused by the extensive use of antibiotics. Efforts to find new materials with antimicrobial effects have been more serious than before. In this study, MgO/MgAl2O4 nanoparticles were synthesized by hydrothermal technique. To investigate the physicochemical properties, scanning electron microscopy, dynamic light scattering, X-Ray Diffraction (XRD), ThermoGravimetric Analysis (TGA), and atomic force microscopy were carried out. For the purpose of evaluation of the MgO/MgAl2O4 nanoparticles, energy dispersive Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), (TGA), Transmission Electron Microscopy (TEM) and Fourier-Transform InfraRed (FT-IR) spectroscopy ran then minimum inhibitory concentration measured on eight bacterial strains. The majority of nanoparticles were in the range of 90 to 150 nm which is the well-optimized size for our purpose. Antimicrobial analysis showed the effect of synthesized MgO/MgAl2O4 NPs on every eight microbial strains including 4-gram positive Staphylococcus epidermidis, Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis and 4-gram negative strains Serratia marcesens, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoni.