Influence of Nanoscopic Micellar Confinements and Rotational Dynamics of Anticancer Drug Doxorubicin

Modulation of photophysical properties and entrapping of fluorescence drug molecules in microhetrogeneous systems are embracing potential applications in therapeutic pursuit. The present contribution describes the fascinating photobehaviour of ananticancer drug Doxorubicin (DOX) in micellar solutions of cationic cetyl trimethylammonium bromide (CTAB), anionic sodium dodecyl sulfate (SDS) and non-ionic p-tert-octylphenoxy polyoxyethanol (TX-100) surfactants by means of steady state, time resolved emission and emission anisotropy procedures. Drug resides at the micelle-water interface in all these micellar systems as revealed by the fluorometric studies. Steady-state anisotropy and rotational relaxation time enhance in the micellar environment compared to it in pure aqueous solution reveal that the drug presents in a motionally constrained environment.