Comparing the Effect of Vi - one Ginger Mouthwash with 100000 IU Nystatin Suspension in Patients with Type - 2 Denture Stomatitis, a Double - Blind Clinical Trial Study

Denture stomatitis is a common disease in people who have dentures. The most important cause of it is Candida albicans. The antifungal properties of ginger have been overviewed in laboratory and systemic usage in previous studies. The present study was designed to evaluate the ginger mouthwash and compare it with the standard antifungal agent.

This study was designed as a double blind clinical trial. It was performed on 50 patients with type-2 denture stomatitis. Each patient was asked to use 5 ml of the drug 4 times a day for 2 minutes. The area of ​​erythema was measured on the first day, and days 7, 14, 21. Erythema changes in each group and at each time compared to the first day were analyzed with paired t-test and between two groups at each stage with t-test and during follow-up with ANOVA test. P < 0.05 was considered significant.

People in both groups were similar in terms of age, sex and erythema on the first day. The rate of erythema changes in the first week of nystatin was 104.1 ± 16.5 mm2 and in ginger 60.9 ± 17.8 mm2 (P < 0.001), and the same was true in the second and third weeks, and their differences were statistically significant (P < 0.001).

Nystatin suspension and ginger mouthwash both appear to be effective in the treatment of denture stomatitis, but nystatin is more effective.