The Efficacy of Long-Pulsed, 1064-nm Nd:YAG Laser Versus Aluminum Chloride 20% Solution in the Treatment of Axillary Hyperhidrosis

Hyperhidrosis (HH) refers to uncontrollable excessive sweating that has a significant negative impact on the quality of life.The aim of this study was to compare the efficacy and safety of the long-pulsed, 1064-nm Nd:YAG laser and aluminum chloride (ALCL3) 20% solution in axillary HH treatment.

In this single-center, within-patient comparison clinical trial, 12 patients with axillary HH were treated monthly for 3 to 4 consecutive sessions with the long-pulsed, 1064-nm Nd:YAG laser system on one axilla, while the contralateral axilla was treated with ALCL3 20 % by the patient. Treatment response was evaluated by comparing the area of sweating at the end of each session and 6 months after treatment termination using the iodine starch test.

Both treatments led to the reduction of HH from baseline with the mean area of sweating reduced from 109.3 ± 36.6 to 38.3 ± 19.8 and from 92.5 ± 31.6 to 35.6 ± 17.1 in laser- and ALCL3-treated axilla respectively (Both P< 0.001). In the 6-month follow-up, the area of sweating was 60.6 ± 29.2 in the laser-treated armpit and 78.3 ± 23.6 in the ALCL3-treated side, which were 45% and 14.4% lower compared to the baseline respectively. Adverse events were temporary, and none caused each of the treatments to be discontinued.

The long-pulsed, 1064-nm Nd:YAG laser with hair reduction setting can stand as a potential therapeutic option for axillary HH since it is as effective as ALCL3. The therapeutic effect is superior in the long term for the laser; nevertheless, the beneficial effect of both treatments may lessen the following treatment cessation.