Study of the level of C-reactive protein and some oxidative stress markers in pregnant and aborted women in the first trimester of pregnancy

Miscarriage is a term that refers to the loss of a pregnancy before twenty weeks of the fetus’s lifespan. This leads to complications and psychological disorders for the aborted woman. Studies are continuing to find out the reasons that lead to miscarriage. To identify the effect of the levels of (CRP), (SOD), (GSH), and (MDA) on pregnancy and miscarriage in the first trimester of pregnancy, the study was conducted in the gynaecologydepartment and maternity hall at Salah al-Din General Hospital / Tikrit City / Salah al-Din Governorate for the period between: "October 2022 to March 2023". The study included 90 samples, 20 samples for the control group the same for the pregnancy group and 50 samples for the abortion group,half is for the one-time miscarriage group and the other half for the recurrent miscarriage group.In this study, we explored the biochemical markers of oxidative stress in various pregnancy-related conditions. Our research focused on assessing the concentrations of C-reactive protein (CRP), Superoxide Dismutase (SOD), Glutathione (GSH), and Malondialdehyde (MDA) in different groups: pregnant women, women with a history of one miscarriage, and women with repeated miscarriages, comparing these to a control group. Our findings revealed that CRP levels showed a notable escalation in groups with pregnancy, one-time miscarriage, and repeated miscarriages, indicating a highly significant difference (P ≤ 0.05) in each case. This pattern suggests a progressive increase in CRP concentration across these groups. Conversely, SOD concentrations did not display significant differences across the groups studied, including the control group, at the P ≤ 0.05 level. This indicates that SOD levels remained relatively stable across different pregnancy conditions. In terms of GSH levels, we observed a highly significant variation (P ≤ 0.05). The pregnant group showed a non-significant increase in GSH compared to the control group. However, both the one-time miscarriage and repeated miscarriage groups exhibited a significant decrease in GSH levels when compared to the control group. Lastly, the analysis of MDA concentrations revealed significant differences (P ≤ 0.05) across the groups. Each of the pregnancy, one-time miscarriage, and repeated miscarriage groups registered a notable decrease in MDA levels in comparison to the control group. This study thus contributes important insights into the oxidative stress markers in various pregnancy-related conditions, highlighting the role and variation of CRP, SOD, GSH, and MDA in these scenarios.