Role of interleukin 18 and macrophage inflammatory protein in Iraqi patients with urolithiasis, An Immunopathological study

The current investigation aimedto assess the IL18 and MIP beta levels in serum patients with urothalisis. Sixty serum samples were collected from the infected people with urothalisis and twenty-eight serum samples from healthy who reviewed Al-Hilla Teaching Hospitaland Imam Sadiq Teaching Hospital. Serum levels of IL18 and MIP were measured by “enzyme-linked immunosorbent assay (ELISA)” which applies a technique called a quantitative sandwich immunoassay using a Peprotech (USA) kit. The concentration of cytokines revealed in this studyIL-18 showed an increase in concentration and reached 46.146 pg/ml compared to the control group. The concentration of MIP beta showed an increase in urothalisis patients than in controls and reached 195.566 with significance (P < 0.05). We conclude that the concentration of IL18 and MIP were higherin patients than in healthy, and the correlation between MIP beta and IL18 was negative and no significant between them.