Lifestyle factors on the long‑term survival of gastric cancer patients after radical resection: A cohort study

This retrospective cohort study aimed to evaluate the effect of lifestyle factors (e.g., smoking, drinking, physical exercise, and sleep duration) on the long‑term survival of gastric cancer (GC) patients after radical resection.

GC patients after radical resection were enrolled from January 2016 to December 2017. Their baseline clinical data, lifestyle factors, and prognosis were collected. The primary endpoint was all‑cause death. The relationship between the variables and survival was examined using the Cox proportional hazards model.

A total of 309 patients were enrolled and 296 patients were followed up for a median of 54.0 months, with 130 confirmed deaths. Older age (>60 years) (hazard ratio [HR]: 1.307, 95% confidence interval [CI]: 1.056–2.161, P = 0.006), advanced tumor, node, and metastasis stage (P < 0.05), poorly pathological differentiation (HR: 1.765, 95% CI: 1.080–2.884, P = 0.023), history of smoking (P < 0.001), never physical exercise (HR: 2.057, 95% CI: 1.170–3.617, P = 0.012), long sleep duration (≥8 h) (HR: 4.160, 95% CI: 1.501–11.533, P = 0.006), and short sleep duration (<6 h) (HR: 3.417, 95% CI: 1.312–8.900, P = 0.012) were independent indicators of a poor overall survival in GC patients after radical resection.

Smoking cessation, proper sleep duration, and regular physical exercise habits can improve the long‑term survival of GC patients after radical resection.