The study of predisposing factors related to perforation in patients with peptic ulcer in shahid beheshti hospital using fuzzy logic, qom, during 2019 to 2022

Gastrointestinal ulcers occur due to an imbalance between the defense mechanisms of the gastric mucosa and damaging forces, especially gastric acid and pepsin. Overall, complications occur in 10%-20% of these patients, and 2%-14% of wounds eventually perforate. The use of non-steroidal anti-inflammatory drugs, steroids, smoking, Helicobacter pylori and high salt diet can be mentioned as important etiologies in this regard.

In this study, the information of patients with peptic ulcer who referred to Beheshti Hospital from 2019 to 2022 was analyzed. They were divided into two groups with perforation and without perforation. Then the variables of age, sex, smoking, NSAID and opium use, Helicobacter pylori infection and proton pump inhibitor use and previous history of peptic ulcer were investigated in two groups.

The findings of the present study showed that the average age in the group with perforation was 48.7 and in the group without perforation was 42.04. In the non-perforated group, 58.5% of the patients were male, and in the group with perforation, 82.2% of the patients were male. In terms of smoking, 29.6% were smokers in the group without perforation and 50.4% were smokers in the group with perforation. Opium consumption was about 15.6% in people without perforation and about 33.3% in people with perforation. In terms of NSAID use, the prevalence was 35.6% in the group without perforation and 27.4% in the group with perforation. PPI consumption was 46.7% in the group without perforation and 21.5% in the group with perforation. In terms of the prevalence of H.pylori infection, the prevalence in the non-perforated group was 45.2% and in the perforated group it was 30.4%. The previous history of PUD was 56.3% in the non-perforated group and 37.8% in the group with perforation.

There was a significant difference between cigarette and opium consumption in the perforated and non-perforated groups, and PPI consumption in these two groups. In general, the prevalence of PUD was higher in males in both perforated and non-perforated types. Fuzzy results also confirmed the effect of risk factors concordance with perforation.