Analytical calculations of platinum-195m production in Tehran research reactor to estimate the required activity in theranostic applications

Platinum agents continue to be the main chemotherapeutic agents used in the treatment of cancer. Cisplatin agents labeled with platinum-195m theranostic radionuclide can potentially be a useful tool to determine the patient's dose and also assist in the investigation of the mechanism of Cis-platinum’s action and its metabolism in the human body. 195mPt radionuclide with suitable nuclear properties can be easily used in the synthesis of platinum-based cytotoxic compounds. In this study, production calculations of platinum-195m in the Tehran Research Reactor (TRR) were performed through the simultaneous solution of differential equations of the decay chains for natural platinum and natural iridium targets using MATLAB software. Natural platinum and iridium targets were irradiated in the TRR and after the radiochemical process, the experimental value of activity of 195mPt resulting from the irradiation of the natural platinum target was compared with the theoretical values. The results showed that there is good compatibility between the measured values experimentally and the results of the theoretical calculations. The results of this research can be used in studies of Cis-platinum labeling with platinum-195m.