Investigation of neuroprotective effects of Aqueous extract of cone leaves of Humulus Lupulus on CA3 region of hippocampus on pentylenetetrazole induced seizures in male mice

  All over the world, about one percent of people are affected by one of most complex neurological disorder, epilepsy. Hippoacampus is one of common region of the brain that affected in human epilepsy.  Despite existence of multiple synthetic drugs for epilepsy management and control, some patients suffer from treatment-resistant seizures and unwanted side effects of available medicine. Therefore, such safe new drug discovering research is emphasized. Because of traditional herbal medicine use as a therapeutic modality also, regarding to beneficial components Humulus Lupulus (H.L). The aim of current investigation was to assess anti-convulsive effects of cone leaves extracts of H.L extract on chemical kindling model of epilepsy and its neuroprotective effects on CA3 region of hippocampus. 

Our findings suggest beneficial anticonvulsive effects for cone leaves extracts of H.L on PTZ kindling neuroprotective effects on hippocampus tissue. This medicinal plant may be beneficial for human seizure treatment so more investigation is proposed.