The Effects Of 8 Weeks of High and Moderate Intensity Interval Training on Irisin and Adipolin Levels in Type 2 Diabetic Male Rats

The purpose of this study was to compare the effects of high and moderate intensity interval training on Irisin and Adipolin levels in type 2 diabetic male rats.

Thirty-two male Wistar rats were divided into two groups: healthy and diabetic, diabetic rats were randomly divided into three subgroups of diabetic control and two HIIT and MIIT groups; so that the present study was performed on four groups (8 per each group). The training was performed with 65-70% and 85-90% of the maximum oxygen consumption in MIIT and HIIT groups, respectively. Twenty-four hours after the last training session, the mice were removed by intraperitoneal injection of a combination of anaesthetic ketamine and xylazine. The levels of Irisin and adipolin were measured by ELISA method. Data were analysed by one-way ANOVA and Tukey's post hoc test.

The results of the post hoc test indicated a significant increase in irisin and adipolin in the HIIT and MIIT groups compared to the control group (p = 0.001). There was no significant difference between HIIT and MIIT groups (p = 0.274).

HIIT and MIIT could lead to a significant increase in irisin and adipolin in diabetic rats.
Keywords: Diabetes, Irisin, Adipolin and interval training.