Chlorpyrifos induced oxidative stress responses and alteration of acetylcholinesterase activity in the olfactory organ of freshwater minor carp, Labeo bata

The sub-lethal toxicity of Chlorpyrifos on selected oxidative stress biomarkers (malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and reduced glutathione (GSH)) and acetylcholinesterase (AChE) activity was examined in the olfactory organ of Labeo bataundersub-lethal exposures. Chlorpyrifos (CPF) was administered at predetermined exposure concentrations (21.93and 36.54μg/L) and monitored on days 15and 30of the experimental periods. The experimental groups showed significantly higher values (P<0.05) of MDA, SOD, CAT, GST and GPx in CPF exposed fish compared to control. AChE and GSH were significantly lower in exposed fish. In general, biomarker depictions indicate that CPF exposures are capable of inducing stress-specific effects at the biochemical and physiological levels negatively impacting the overall health and longevity of such animals